IMPROVING THE CRITERIA FOR EARLY DIAGNOSIS OF HYDATIDIFORM MOLE AND RISK STRATIFICATION IN THE ARAL SEA REGION

Abstract: Recent advances in cellular biology and diagnostic technology have improved gynecological disease management and fertility preservation. Early detection of conditions like hydatidiform mole is linked to better outcomes, while appropriate treatment and careful monitoring increase the chances of a successful pregnancy and healthy childbirth.
Aim: To evaluate the role of immunohistochemical analysis in detecting malignant transformation of hydatidiform mole in women residing in the Aral region and to develop a comprehensive management algorithm for these patients.
Study design: An open-label, independent prospective study.
Materials and methods: A total of 70 endometrial aspirate samples from women diagnosed with hydatidiform mole were analyzed. The samples were collected between 2019 and 2022.
Conclusion: Successful pregnancy outcomes require precise regulation and interaction between specific hormones and their respective receptors. Dysregulation or aberrant expression within any of these pathways may lead to implantation failure or pregnancy loss.