EFFICACY AND SAFETY OF POMEGRANATE SEED OIL AS PART OF THE COMPREHENSIVE TREATMENT OF PATIENTS WITH ACUTE KIDNEY INJURY

Pomegranate seed oil (PSO) is rich in punicic acid, a conjugated linolenic  acid associated with antioxidant and anti-inflammatory activity in experimental  models. These properties create a plausible rationale for studying PSO as an adjunct to  standard treatment during recovery from acute kidney injury (AKI). This narrative  review evaluates the efficacy and safety evidence relevant to that proposal. Animal  studies of gentamicin-, cisplatin-, mercury-, and other toxin-associated renal injury  have reported lower oxidativestress, improved biochemical markers, and less  histological damage with PSO. Human trials of PSO have been conducted in hyperlipidemia, type 2 diabetes, menopausal symptoms, and mild cognitive  impairment, but not specifically in patients with AKI.