PREDICTIVE VALUE OF CLINICAL AND NEUROPSYCHOLOGICAL INDICATORS FOR THE EFFECTIVENESS OF PREVENTIVE THERAPY IN MIGRAINE

Response to preventive migraine therapy varies considerably among patients. This thesis  summarizes the predictive significance of clinical phenotype, disease burden, psychoemotional  status, and cognitive-executive functioning for treatment outcomes. Current evidence suggests that  unilateral pain, cranial autonomic symptoms, good response to triptans, and a relatively lower  baseline disease burden may be associated with a favorable response to selected CGRP-targeted  therapies. In contrast, chronic migraine, high MIDAS/HIT-6 scores, obesity, depressive and anxiety  symptoms, and multiple previous preventive treatment failures are associated with less favorable  outcomes. A multidimensional assessment may therefore improve individualized preventive  treatment planning.