MICROBIOLOGICAL FACTORS IN THE DEVELOPMENT OF CHRONIC PERIODONTITIS AND THEIR PATHOGENETIC SIGNIFICANCE

This article examines the role of microbiological factors in the development of chronic periodontitis and their pathogenetic significance. Chronic periodontitis is a multifactorial inflammatory disease of periodontal tissues characterized by progressive destruction of connective tissue attachment and alveolar bone, eventually leading to tooth loss. While systemic and local risk factors such as immune status, metabolic disorders, and poor oral hygiene play essential roles, the microbiological component remains central to its initiation and progression. The paper highlights the complex interactions between periodontal pathogens, host immune responses, and biofilm formation. Comparative data from both classical and modern studies illustrate the transition of periodontal microbiota from commensal to pathogenic states. The analysis emphasizes the pathogenic mechanisms of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia, and their synergistic interactions with other microorganisms. The results underscore the importance of early microbiological diagnosis, targeted antimicrobial therapy, and host modulation strategies in the management of chronic periodontitis.