INTEGRATED ASSESSMENT AND MATHEMATICAL MODELING OF CEREBROVASCULAR REACTIVITY IN PATIENTS WITH CAROTID AND CORONARY ATHEROSCLEROSIS

Combined atherosclerotic lesions involving both the carotid and coronary arterial basins  constitute a highly critical clinical state, exponentially elevating the risk of synchronous ischemic  strokes and myocardial infarctions. Cerebrovascular reactivity (CVR) represents the fundamental  compensatory capacity of the cerebral microvasculature to dilate or constrict in response to metabolic  and hemodynamic shifts. While structural assessments like lumen stenosis are standard, they often  fail to capture latent perfusion failures, necessitating multi-parametric functional modeling