Reproductive, Metabolic, and Cardiovascular Consequences of Premature Ovarian Insufficiency: A Critical Integrative Review of Clinical Evidence, RealWorld Data, and Precision Care

 Premature  ovarian  insufficiency  (POI),  defined  by  impaired  ovarian  activity  before  40  years  of  age,  represents  a  multisystem  diagnosis  rather  than  an  isolated  fertility  disorder.  Its  consequences  involve  hypoestrogenism,  intermittent  ovarian  function,  impaired  reproductive  autonomy,  skeletal  vulnerability,  cardiometabolic  risk,  and  substantial  psychosocial  burden.  Objective:  To  critically  integrate  contemporary  evidence  regarding  reproductive,  metabolic,  and  cardiovascular  sequelae  of  POI,  and  to  assess  how  real-world  evidence  and  computational tools may improve longitudinal care. Methods: