HISTOMORPHOLOGICAL CHANGES IN INTERVERTEBRAL DISCS OF OFFSPRING EXPOSED TO EXPERIMENTAL HYPOTHYROIDISM: THE IMPACT OF HYPODYNAMIA

This article examines the impact of hypodynamia on the histomorphological  characteristics  of  intervertebral  discs  in  offspring  developed  under  conditions  of  experimental hypothyroidism. Particular attention is given to the potential structural  alterations  in  the  nucleus  pulposus,  annulus  fibrosus,  and  cartilaginous  endplates  associated with thyroid hormone deficiency and reduced physical activity. The study  focuses  on  changes  in  cellular  organization,  extracellular  matrix  composition,  and tissue  architecture,  emphasizing  the  possible  combined  effects  of  endocrine  dysfunction and mechanical unloading.