THE ROLE OF III GENERATION CEPHALOSPORINS IN THE TREATMENT OF URINARY TRACT INFECTIONS

Treatment of lower urinary tract infections, such as cystitis or asymptomatic bacteriuria, is often more difficult in practice than it appears at first glance. The choice of antibacterial drugs should be made taking into account the effectiveness, side effects, as well as their cost and availability, proven in clinical studies. Many results of epidemiological studies show a steady increase in the resistance of uropathogens to antibiotics, which, in turn, leads to an increase in the number of treatment failures and repeated forms of the disease. Fosfomycin and nitrofurans are recommended as first-line drugs, taking into account that when choosing an antibiotic, preference should be given to drugs with a low risk of selecting resistant microorganisms. According to the current clinical guidelines, it is recommended to use third-generation cephalosporins as an alternative therapy for lower urinary tract infections, including in pregnant women, allergy, lack of sensitivity of the pathogen or ineffective treatment for the first time. The article presents information on the effectiveness of third-generation cephalosporins in the treatment of lower urinary tract infections.